Pinnacle of Intellect

Pinnacle of Intellect 

What if you could upgrade the mind in all ways imaginable?

Want to attain the pinnacle of intellectual potential?

This project focuses on cognitive enhancement, the brain being as complex as it is, there are many different ways to do that. Brain wiring (that is enhancing or even creating new circuitry in the brain), genetic regulation, genetic mutations, chemical stimulants and simulants as well as the manipulation of a never ending list of neurotransmitters, the list goes on and on. The purpose of the described concept is to create a comprehensive and enhanced cognitive system that integrates various extraordinary neurological capabilities and mechanisms to achieve superior brain function.

-> Activate PKMCZ (a potent primer that sets the stage for the reactivation of dormant engrams, memory traces long buried beneath the layers of time. PKMCZ doesn’t just nudge forgotten memories to the surface—it restores them, breathing life into what was once thought lost. It acts as the catalyst, priming the brain for the next phase of enhancement, ensuring that these old memories are ready for reinforcement by the suite of cutting-edge mutations that follow)

Activate α-Tubulin (E55K, H283Y) and β-Tubulin (K350N) mutations, both newly formed and restored by PKMCZ

enhance microtubule stability

Activate N-Cadherin (R714G and I75D) mutations 

Activate Neuroligin-1 (R451C) mutation 

Optimise brain by Neuroligin-1 mutations to become hyper-adaptive

Activate EphB2 mutation

Enhance EphB2’s activity 

Activate AMPAR receptors, stabilized by GRIP1 and GRIP2

the GRIP-enhanced AMPAR network to lead to faster neural processing

Stargazing proteins add an additional layer of reinforcement by ensuring that AMPAR receptors remain in their optimal positions at the synapse

At the structural level, enhance integrins(α3β1, α5β1, αvβ3) provide the scaffolding necessary for new synaptic connections to be fully anchored

Use Transcranial Direct Current Stimulation (tDCS), which delivers a constant, low-level electrical current (1–4 mA) via electrodes placed on the scalp. This boosts ongoing neuronal activity without triggering action potentials, keeping memory circuits primed

Focus on the entorhinal cortex, which plays a critical role in memory formation and recall. Place the anode electrode over this region for tDCS

For improved neural synchrony, consider pairing tDCS with transcranial alternating current stimulation (tACS), which applies oscillating currents to synchronize brain regions involved in memory and coordination tasks

Combine stimulation with EEG or MEG hyperscanning to monitor neural synchrony and adjust parameters dynamically for optimal synchronization and memory enhancement

NR2B overexpression synergistically with Clotho and Cloq10

Recombinant NGF-ß overexpression

4'-DMA-7,8-DHF overexpression

LM22B-10 overexpression

Des(1-3)IGF-1 overexpression 

Recombinant human CNTF (Axokine) overexpression

Activate 8-Bromo-cAMP by maintaining prolonged signalling pathways

CDPPB overexpression

Activate Carbachol

Upregulate BDNF expression and activating related signaling pathways to activate CX614

Enhance the structural foundation of your neural networks through the overexpression of SHANK3 and PSD95

Overexpression of Homer-1 to refine synaptic signalling, setting the stage for the activation of PKC (Protein Kinase C) by PMA (Phorbol 12-myristate 13-acetate)

In the nucleus, activate CREB (cAMP response element-binding protein)

upregulation of FOS (cFos) and JUN (cJun)forms the AP-1 dimeric complex

Activate TrkA, TrkB, and TrkC receptors, encoded by the NTRK1, NTRK2, and NTRK3 genes

Activate IGF-1R, encoded by the IGF1R gene, and C-MET, encoded by MET

Activate AMPAR, the receptor encoded by the GRIA1-4 genes to work synergistically with P75NTR, encoded by NGFR, to fine-tune the brain’s response to growth factors (making the brain more receptive to subsequent neurogenesis interventions)

Activate CNTFR, encoded by the CNTF gene

Activate mAChR and nAChR receptors, encoded by CHRM and CHRN genes

Activate mGluR5, encoded by the GRM5 gene, and GRIN2B, a receptor encoded by the GRIN2B gene

Activate SMO, encoded by the SMO gene

Ras-related C3 botulinum toxin substrate 1 (Rac1(Q61L)) and Cell division cycle 42 (Cdc42(Q61L)) overexpressed

Activate WASP-family verprolin-homologous protein (WAVE) regulatory complex, comprised of Specifically Rac1-associated protein 1 (Sra1) and Hematopoietic stem/progenitor cell protein 300 (HSPC300)

Activate p21-activated kinase 1 (PAK1), as a downstream effector of Rac1 and Cdc42 (this amplifies the activation cascade, driving the enhanced neuronal morphology required for higher-order cognitive functions

Activate the Actin-related protein 2/3 (Arp2/3) complex, encompassing Actin-related protein 2 (Arp2), Actin-related protein 3 (Arp3), and associated subunits (ARPC1, ARPC2, ARPC3, ARPC4, and ARPC5, synergizes with the WAVE complex to induce the formation of branched actin networks, crucial for robust cytoskeletal remodelling

Coordinated expression of NCK-associated protein 1 (Nap1) and End-binding protein 3 (EB3)

Activate Developmentally regulated brain protein (Drebrin)

(What would happen if we provided our brains with a supernatural amount of its primary energy currency for it to spend on repair, healing, growth and cognitive performances with complete abundance ?)

Proteins are produced with RNA:

Activate Intracellular Adenosine, bypassing the brain’s natural production pathways ensures an abundant supply of this vital precursor to ATP, the coordinated action of Adenosine Kinase and Adenylate Kinase accelerates the conversion of adenosine into usable energy, ensuring a steady and amplified flow of ATP within neurons (which supports not only cognitive function but also cellular repair and regeneration)

Augment the role of FAD (flavin adenine dinucleotide) and NAD+ (nicotinamide adenine dinucleotide)

Within the mitochondria, the over-expression of ATP5F1A, ATP5F1B, ATP5F1C, and ATP5MC1 optimizes the function of ATP synthase

Upregulate Cytochrome C Oxidase, the final enzyme in the electron transport chain

Activate photobiomodulation—the use of light to enhance mitochondrial function

Activate Rhodopsin proteins in the mitochondria by 499nm green light, triggering additional pathways that elevate energy production (this light-responsive mechanism enhances the mitochondria’s ability to generate ATP, contributing to improved cellular communication and synaptic plasticity)

Activate CoQ10 (an electron transporter and antioxidant, protecting mitochondria from oxidative damage while ensuring efficient energy production)

Upregulate Neuroglobin protein alongside Mitoquinol to neutralize free radicals, safeguarding mitochondrial health while enhancing energy production.

Extremely high sensitivity, density and expression of androgen receptors in pituitary, hypothalamus, hippocampus, amygdala, nucleus accumbens 

Enhance brains neural stem cells differentiation into androgen receptors expressing neurons 

Optimized development of new androgen receptors in prefrontal cortex 

Heightened neurogenesis and synaptic plasticity    

Optimally high neurotrophic factors 

Optimized neurosteroidogenesis for optimal DHT, allopregnanolone etc production 

Modulation of glucocorticoid receptors to reduce stress induced androgen suppression

Enhance 5AR expression in brain